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KMID : 1134819980270030518
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 3 p.518 ~ p.524
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The Effects of Godulbaegi Extracts on the Fluidity of Phospholipid Liposomes by DSC
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Bae Song-Ja
Kim Nam-Hong
Rho Sung-Bae
Jung Bok-Mi
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Abstract
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Liposomes have been widely employed as biomembrane-mimetic system and drug-delivery system. In these applications, the low stability of liposomes has been the most serious problem. They have relatively short half-lives and are easily lysed through interactions with biological components. This study was performed to investigate the effects of godulbaegi extracts on the fluidity of phospholipid liposomes. We used dipalmitoyl phosphatidylcholine(DPPC) liposomes which make most stable liposomes among the other phosphatidylcholines. The thermograms of the DPPC liposomal bilayers incorporated with the hexane extract of godulbaegi(Ixeris sonchifolia H.) were obtained, and the enthalpy changes and the sizes of cooperative unit of the transition were calculated. The incorporation of the Ixeris sonchifolia H. into the liposomal bilayers effectively reduced the transition temperature at which the transition from gel state to liquid-crystalline state occurs, broadened the thermogram peaks, and reduced the ratio of van’t Hoff to calorimetric enthalpies. These results indicate that the godulbaegi extracts (Ixeris sonchifolia H.) have significant effects on the fluidity of biological membranes.
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KEYWORD
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DPPC, Ixeris sonchifolia H., DSC, fluidity, membrane mimetic system
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